Effects of maternal hypoxia on placental levels of oxidative stress markers in COMT-/- and C57 mice
نویسندگان
چکیده
Introduction In preeclampsia, it is believed that widespread endothelial dysfunction leads to reduced placental perfusion and increased oxidative stress. Oxidative stress is the accumulation of reactive oxygen species (ROS) such as superoxide (O2-), nitric oxide (NO), and peroxynitrite (ONOO-). Our lab has previously established a colony of transgenic mice that do not express catechol-Omethyl transferase (COMT-/-). COMT produces 2methoxyestradiol (2-ME), a potent vasodilator that is normally increased in pregnancy. Pregnant COMT-/mice exhibit a phenotype similar to the one observed in preeclampsia. We hypothesize that COMT-/mice have a decreased tolerance to prenatal hypoxic insults, characterized by an increase in placental oxidative stress when compared to control (C57) mice exposed to similar conditions.
منابع مشابه
The Effects of Testosterone on Oxidative Stress Markers in Mice with Spinal Cord Injuries
Objective Spinal cord injury (SCI) causes infertility in male patients through erectile dysfunction, ejaculatory dysfunction, semen and hormone abnormalities. Oxidative stress (OS) is involved in poor semen quality and subsequent infertility in males with SCI. The aim of this study is to examine the effects of SCI on the level of testosterone hormone. MaterialsAndMethods In this experimental st...
متن کاملProtective effect of N-acetylcysteine on Dipentyl phthalate (DPeP) induced cognitive dysfunction and brain oxidative stress in mice
Background: Dipentyl phthalate (DPeP) is a plasticizer compound commonly used in polyvinylchloride plastic to increase their softness and flexibility. They are not bound covalently to the plastic polymers and can therefore leach out into the environment, and have been shown to adversely affect the health of humans and animals. Methods: We investigated the effect of DPeP on the various cognitive...
متن کاملSynergism effects of pioglitazone and Urtica dioica extract in streptozotocin-induced nephropathy via attenuation of oxidative stress
Objective(s): Hyperglycemia promotes oxidative stress that plays a crucial role in the pathogenesis of Diabetic nephropathy (DN). In this study, we investigated the synergism effects of hydroalcoholic extract of Urtica dioica and pioglitazone (PIO) on the prevention of DN in streptozotocin induced-diabetic mice. Materials and Methods: Forty-two mice were divided into six groups as follows: non-...
متن کاملP-58: BSO-Induced Oxidative Stress Affects Testicular Ultrastructure, Levels of Oxidative Markers, Testosterone and Sperm Fertility
Background: GSH is the main intracellular antioxidant and its level is important for protecting cell from oxidative stress. BSO inhibits GSH synthesis and cause oxidative stress. The study is designed to investigate the effect of BSO induced oxidative stress on testicular histology, semen parameters and sperm fertility. Materials and Methods: The adult male mice were divided into two groups of ...
متن کاملP-85: Evaluation of Sperm Fertility Quality in Phenyl Hydrazine-Induced Hemolytic Anemia Impacts on Mice
Background: Anemia and consequently low oxygen can cause changes in the function and structure of the testis and spermatogenesis, Iron released from red blood cells, followed by the increased oxidative stress, which may cause tissue iron. This study was designed to minimize the deleterious effects of hypoxia on the genitals. Materials and Methods: Eighteen mature male mice were randomly divided...
متن کامل